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Rybersus (GLP-1)

マイクロニードルRFポテンツァの次世代機器 マイクロニードルRFポテンツァの次世代機器

The diet effect of Rybelsus! Does it really help with weight loss? Explanation on usage, side effects, and risks

Rybelsus is an oral medication containing GLP-1, often referred to as the "slimming hormone."

Taking Rybelsus helps suppress appetite, potentially leading to weight loss without experiencing stress. It's also known to enhance visceral fat burning and improve basal metabolism, making it suitable for those looking to improve their overall body composition.

This page explains Rybelsus's characteristics, expected effects, potential side effects, and risks. Additionally, it provides three strategies for those who feel Rybelsus isn't helping them achieve weight loss.

For anyone aiming to achieve their ideal body shape without rigorous exercise or strict dieting, Rybelsus could be an essential consideration.

Recommended for Those
with Such Concerns

  • People who struggle to continue with their diet
  • People who feel significant stress when restricting their diet
  • People who wish to avoid surgical procedures
  • People who prefer to avoid self-injection for administering GLP-1
  • People concerned about visceral fat
  • People who don't have time to start a diet
This Treatment is Perfect
for Such Concerns

What is Rybersus (GLP-1) ?

Rybelsus contains semaglutide, a component known for its effectiveness in weight loss and classified as a GLP-1 receptor agonist.

While most GLP-1 receptor agonists are administered via injection to deliver GLP-1, Rybelsus is notable for its oral administration capability.

It not only stimulates insulin secretion to lower blood glucose levels but also regulates gastrointestinal movement, thereby suppressing appetite. Due to its ability to lower blood glucose levels, it is used as a treatment for type 2 diabetes.

Rybelsus tablets obtained manufacturing and marketing approval domestically on June 29, 2020, and were listed under the drug price standard on November 18 of the same year.

Source: Ministry of Health, Labour and Welfare “Regarding Newly Approved Drugs”

Attachment for Rybersus

Based on the package insert for Rybelsus (a document attached to Rybelsus that includes precautions, usage and dosage, efficacy, side effects, etc.), the following information is provided by Novo Nordisk Pharma Ltd., the manufacturer and distributor.

Rybelsus Tablets 3mg


© 2020 Novo Nordisk Pharma Ltd. All Rights Reserved. Source: Novo Nordisk Pharma Ltd. "Product Information Rybelsus®"

Table Example
Active IngredientSemaglutide (genetically modified) 3mg per tablet
AdditivesSodium salcaprozate, Povidone, Microcrystalline cellulose, Magnesium stearate


Rybelsus Tablets 7mg


© 2020 Novo Nordisk Pharma Ltd. All Rights Reserved. Source: Novo Nordisk Pharma Ltd. "Product Information Rybelsus®"

Table Example
Active IngredientSemaglutide (genetically modified) 7mg per tablet
AdditivesSodium salcaprozate, Povidone, Microcrystalline cellulose, Magnesium stearate


Rybelsus Tablets 14mg


© 2020 Novo Nordisk Pharma Ltd. All Rights Reserved. Source: Novo Nordisk Pharma Ltd. "Product Information Rybelsus®"

Table Example
Active IngredientSemaglutide (genetically modified) 14mg per tablet
AdditivesSodium salcaprozate, Povidone, Microcrystalline cellulose, Magnesium stearate

The reason why Rybelsus is trending

GLP-1 receptor agonists have become a hot topic, especially on social media, leading to widespread usage. However, since GLP-1 receptor agonists were previously only available as subcutaneous injections, people who are "afraid of injections" or "hesitant to self-administer" found it difficult to adopt.

On the other hand, Rybelsus, which can be taken orally, saw explosive popularity after it filed for approval in Japan in July 2019 and received manufacturing and marketing approval in June 2020.

GLP-1 receptor agonists are recognized as relatively safe drugs because they are less likely to cause hypoglycemia when taken alone.

Differences between Rybelsus and Saxenda

Rybelsus and Saxenda, both GLP-1 receptor agonists, have notable differences. While Rybelsus is an oral medication, Saxenda is administered via self-injection.

Additionally, there is a difference in the effectiveness of the two drugs, with Rybelsus being regarded as a medication that is "expected to have a higher weight loss effect."

How Rybelsus (GLP-1) Works

The GLP-1 in Rybelsus promotes insulin secretion, which helps control blood glucose levels and suppresses appetite. Therefore, what is commonly referred to as the “GLP-1 diet” involves using medications that utilize the hormone GLP-1 for weight loss.

GLP-1 not only promotes insulin secretion to control blood glucose levels and suppress appetite, but it also controls gastrointestinal function. By slowing down the movement of the digestive tract, the digestion speed of food decreases, allowing you to feel full with a smaller amount of food.

Additionally, it slows down the absorption of food, which in turn slows down the absorption of sugars. This prevents a rapid rise in blood glucose levels after eating and helps reduce postprandial hyperglycemia. These mechanisms help suppress appetite.

Rybelsus is a type of medication known as a GLP-1 receptor agonist. GLP-1 receptor agonists are drugs that mimic the action of the hormone GLP-1.

The GLP-1 hormone present in the body is secreted from the small intestine when blood glucose levels rise after eating, promoting insulin secretion from the pancreas. When the amount of insulin increases due to the action of GLP-1, the amount of sugar in the blood decreases, which lowers blood glucose levels and makes it easier for cells such as muscle cells to use sugar as an energy source.

By utilizing this mechanism, it becomes easier to consume sugar. Moreover, Rybelsus is thought to help aim for a body constitution that burns calories more easily.

Reference: rybelsus / MSD Connect

Features of Rybelsus (GLP-1)

  • POINT
    1

    Taking medication without using a syringe

    GLP-1 receptor agonists are mostly administered via injection to deliver GLP-1, but Rybelsus can be taken orally.

  • POINT
    2

    Appropriate dosage adjustment is possible

    Rybelsus is available in 3mg, 7mg, and 14mg doses. We will consult with you to adjust the dosage as needed while you are taking the medication.

Reasons Why MY Beauty Clinic is Chosen

POINT
1

Consultation with highly specialized doctors

At our clinic, experienced doctors and staff provide thorough counseling and examinations. Rybelsus is not a medication that can be prescribed to everyone, so it is necessary for a specialist to carefully examine and make a judgment. Depending on your condition and health, we may recommend alternative treatments. A doctor with experience as a chief of a university hospital's department of plastic surgery will provide personalized consultations for each patient. Please feel free to visit us.
POINT
2

Enhance effectiveness by combining with other treatments

At our clinic, we prescribe not only Rybelsus but also Saxenda as part of our GLP-1 diet program. In addition to the GLP-1 diet, we offer a variety of medical weight loss devices and medications, allowing us to propose the most suitable program tailored to each patient's needs.

Improvement Effects of
Liberthas (GLP-1)

  • 01

    suppress appetite

    It controls the function of the gastrointestinal tract, making it easier to feel full with less food than usual.
    It also acts on the satiety center to reduce hunger and suppress appetite.
    Furthermore, it slows down the rate at which food is absorbed, gradually decreasing the absorption of sugars.
    This prevents a rapid rise in blood sugar levels after meals and helps reduce postprandial hyperglycemia.

  • 02

    It becomes easier to metabolize sugars.

    The GLP-1 hormone, which naturally exists in our bodies, is secreted from the small intestine when we eat and blood sugar levels rise, prompting the pancreas to release insulin.
    Through the action of GLP-1, which increases the amount of insulin, the level of sugar in the blood decreases, leading to a reduction in blood sugar levels.
    Utilizing the principle that cells in muscles and elsewhere can more easily consume sugar as an energy source, Liberthas targets GLP-1.

  • 03

    It turns the body into one that easily burns calories.

    If you feel like you are eating the same amount as when you were younger but have become more prone to gaining weight and find it harder to lose weight, it may be due to changes in the function of fat cells due to aging.

    Fat cells include “white fat cells” that store visceral and subcutaneous fat, and “brown fat cells” that burn fat. The active functioning of brown cells makes the body more capable of burning calories. However, the activity of brown fat cells declines with aging and obesity.

    This means that as you age, the number of brown fat cells decreases and the amount of visceral fat increases due to obesity, leading to a reduced capacity of brown fat cells that should ideally be burning fat.

    As you age, even if you eat the same amount as when you were younger, the reduction in number and activity of brown fat cells makes it harder for your body to burn calories.

    Liberthas targets the functioning of these brown fat cells, making it easier to achieve a body that can readily burn calories.

    Moreover, Liberthas is considered a medication with a higher weight loss effect compared to Saxenda.

Case Photos of Rybelsus (GLP-1)

  • BEFORE
    ▶
    AFTER
    Symptoms
    Patients who have been taking Rybelsus for 6 months. Combined treatment with CoolSculpting Elite and fat-burning IV drip.
    Total Cost
    ¥445,600–634,000 (tax included)
    Side Effects
    Weight: -15.1 kg

How to take Rybelsus (GLP-1)

Rybelsus should be taken correctly by following the prescribed dosage and instructions. The medication is most effective when taken once a day on an empty stomach.

The GLP-1 hormone in the body is quickly broken down, resulting in a short duration of effect. However, Rybelsus has been modified to work longer with a once-daily dose, providing extended effects.

It is recommended to take Rybelsus on an empty stomach, such as upon waking up, with half a glass of water. To avoid poor absorption due to food or drink contents in the stomach, it is advisable to refrain from eating or drinking for 30 minutes after taking Rybelsus. Additionally, if you plan to take other medications, wait at least 30 minutes after taking Rybelsus before doing so. Since tea and coffee can also affect its absorption, it is important to take Rybelsus with water only.

Side Effect Risks

This is a free medical service.
Please declare if you fall under the following categories as you cannot receive treatment.

Notes

Individuals with severe gastrointestinal disorders, minors, and those over 60 years old are also not eligible to take Rybelsus. Additionally, based on a physician's assessment, there may be other cases where it is advisable to refrain from taking Rybelsus.

At our clinic, a doctor prescribes Rybelsus after confirming the results of a blood test. If you have any ongoing medical conditions or are taking other medications, please inform the doctor during the consultation.

Regarding the contraindications for the combined use of Rybelsus:

There are no medications that are strictly contraindicated for use with Rybelsus. However, when used in combination with other diabetes medications, there is an increased risk of hypoglycemia, so caution is needed.

Additionally, when used in combination with the thyroid medication levothyroxine (Thyradin®), there is a potential for the effects of levothyroxine to be enhanced. If you are taking both of these medications, please consult with a specialist.

Side Effects of Rybelsus

As with any medication, Rybelsus also has potential side effects, which include the following:

■ Hypoglycemia
■ Dizziness
■ Gastrointestinal issues (constipation, nausea, diarrhea, etc.)
■ Indigestion

At MY Beauty Clinic, a doctor will always conduct a medical consultation before prescribing Rybelsus, thereby reducing the risk of side effects. Gastrointestinal issues may lessen with continued use.

To minimize the occurrence of side effects, it is recommended to start with a lower dose and gradually increase it under the guidance of a doctor.

【How to Take】The Correct Way to Take Rybelsus

To ensure the effectiveness of Rybelsus, proper intake and storage are essential. Rybelsus should be taken on an empty stomach before the first meal of the day. It is recommended to take it upon waking.

Take one prescribed Rybelsus tablet with approximately half a glass of water (about 120 mL or less). Eating or drinking immediately after taking Rybelsus can prevent the active ingredient from being absorbed properly, thereby reducing its effectiveness.

Therefore, it is recommended to wait at least 30 minutes after taking Rybelsus before eating or drinking anything.

Copyright © 2024 Merck & Co., Inc., Rahway, NJ, USA and its affiliates. All rights reserved. Source: MSD's Key Products Rybelsus® TOP

Points to Note When Taking Rybelsus

Rybelsus is sensitive to moisture and light, so be sure to remove the tablet from its blister pack just before taking it. Additionally, do not split, crush, or chew the tablet; swallow it whole to ensure its effectiveness.

When taking Rybelsus, it is important to use approximately 120 ml of water and avoid taking it with tea, coffee, or medication jellies.

The Risks of Importing the Cheapest Rybelsus Individually

Searching for the cheapest Rybelsus online and obtaining it through individual importation is very dangerous. The personal importation of pharmaceuticals carries a high risk of health hazards, and the Ministry of Health, Labour and Welfare has issued warnings against it.

Source: Ministry of Health, Labour and Welfare "For those who are considering purchasing pharmaceuticals from overseas"

What to Do If Rybelsus Is Not Effective or You Are Not Losing Weight

When taking Rybelsus, weight loss is expected. However, if you do not see any changes after several months of starting Rybelsus, please consider the following points:

Increase the dosage

Rybelsus is a medication that is started at a low dose and gradually adjusted according to your condition and body type. Initially, a continuous dose of 3 mg is taken, and if there are no issues with side effects, the dose can be increased to 7 mg.

For those who do not see any effects from taking Rybelsus, the doctor may assess your symptoms and condition during a consultation and can increase the dose up to a maximum of 14 mg.

If you are taking 3 mg or 7 mg of Rybelsus and do not notice any effects, please consult a specialist doctor to consider adjusting your dosage.

Do not stop taking Rybelsus on your own without consulting a doctor.

You might feel anxious, wondering "When will I see results?" or "It's not working...". However, avoid increasing the dosage or stopping the medication on your own.

If you stop taking Rybelsus on your own, your body may not be accustomed to the eating habits regulated by the medication, making it easier to revert to previous eating habits and increasing the risk of rebound weight gain.

The timing of when you start to see effects from Rybelsus varies from person to person, so it is not possible to definitively say when you will notice results. If you do not feel the effects of Rybelsus or have any doubts or concerns about continuing the medication, please consult your doctor.

Follow the correct method of intake

Rybelsus may not be effective if it is not taken on an empty stomach with 120 ml or less of water. Review whether you are taking it correctly.

Incorrect intake methods can lower the absorption rate of the medication, making it harder to experience the expected effects. Please review the guidelines on "How to Take Rybelsus Correctly" and ensure you follow the correct method of intake.

Review Your Lifestyle Habits

While taking Rybelsus, there is generally no need for extreme dietary restrictions or intense exercise. However, reassessing your diet and incorporating moderate exercise alongside Rybelsus can make it easier to experience weight loss effects.

By reviewing and improving your lifestyle habits, you can more efficiently achieve your target weight and attain your desired body shape.

Treatment Process

  • 1

    Reservation

    Please make a reservation by phone, through the reservation form on our official website, or via LINE.
  • 1

    Reservation

    Please make a reservation by phone, through the reservation form on our official website, or via LINE.
  • 2

    Counseling and Consultation

    We will carefully conduct counseling to understand your concerns and wishes, followed by a thorough consultation with a specialist doctor to propose the most suitable treatment. If you have any questions, please feel free to ask.
  • 2

    Counseling and Consultation

    We will carefully conduct counseling to understand your concerns and wishes, followed by a thorough consultation with a specialist doctor to propose the most suitable treatment. If you have any questions, please feel free to ask.
  • 3

    Blood Test

    At our clinic, we ensure safety by always conducting a blood test. Blood test fee: ¥5,500 (tax included)
  • 3

    Blood Test

    At our clinic, we ensure safety by always conducting a blood test. Blood test fee: ¥5,500 (tax included)
  • 4

    Prescription of Medication

    Medication intake will begin according to your symptoms.
  • 4

    Prescription of Medication

    Medication intake will begin according to your symptoms.

Price Guide

Rybelsus Tablets 3mg
30 Day Supply
8,768 Yen (Tax Included)
Rybelsus Tablets 3mg
30 Day Supply
8,768
Yen (Tax Included)
Rybelsus Tablets 7mg
30 Day Supply
20,454 Yen (Tax Included)
Rybelsus Tablets 7mg
30 Day Supply
20,454
Yen (Tax Included)
Rybelsus Tablets 14mg
30 Day Supply
30,679 Yen (Tax Included)
Rybelsus Tablets 14mg
30 Day Supply
30,679
Yen (Tax Included)
In addition, an initial consultation fee of 3,300 yen (including tax) will be charged, and for subsequent consultations, a fee of 1,100 yen (including tax) will apply.

For online consultations, the consultation fee is free, but there is a system usage fee of 330 yen (including tax) for the online consultation tool "curon," as well as a delivery fee of 550 yen (including tax) to your home.

Additionally, for safe treatment at our clinic, we require "blood test data" from the past year (data from regular health check-ups is sufficient).

If you do not have recent blood test data, you can undergo a blood test at our clinic for 5,500 yen (including tax) after your visit.

Frequently Asked Questions

Q
How many days' worth of LibelSAS can you purchase?
A
At our clinic, prescriptions for LibelSAS can be purchased for up to 30 days per prescription.
Q
Does weight drop immediately after taking it?
A
The timing to feel the effects of LibelSAS varies among individuals. Some may experience immediate weight loss, while others may see weight reduction effects several months later. Typically, it is recommended to use it for about 3 to 4 months to notice results. Incorporating moderate exercise and dietary adjustments while taking LibelSAS can help achieve weight loss effects sooner.
Q
Is it covered by insurance?
A
LibelSAS is covered by insurance when prescribed as a treatment for type 2 diabetes. However, when prescribed for the purpose of weight loss, it is considered self-pay.
Q
When does weight loss start after taking LibelSAS?
A
After taking LibelSAS, some people may experience weight loss as early as one month, while for most, it typically takes around 3 to 4 months to notice the effects. However, the timing to feel the weight loss effects can vary among individuals, not just with LibelSAS but with any diet regimen.

Maintaining a regular lifestyle with moderate exercise and balanced nutrition alongside taking LibelSAS can help individuals experience its effects more effectively.
Q
Currently pregnant (planning to become pregnant, or breastfeeding), can LibelSAS be used?
A
LibelSAS cannot be taken by those who are pregnant, breastfeeding, or planning to become pregnant. If you wish to take LibelSAS, please consult your doctor after weaning and once your health condition has stabilized.
Q
Can LibelSAS be purchased through online shopping?
A
LibelSAS is not approved for sale in Japan, so it cannot be purchased from online platforms like Amazon or Rakuten.

To obtain LibelSAS, one option is to use a proxy service to import it directly from overseas through personal importation. However, there is a risk of receiving counterfeit products when importing LibelSAS from abroad, making this a risky method.

It is recommended to obtain LibelSAS through a medical institution where you can receive a prescription tailored to your specific health needs. This ensures that you are using the medication as directed by a healthcare professional.

Detailed Information

Precautions The following individuals are not eligible to take medication: Pregnant women, breastfeeding mothers, those planning to become pregnant Individuals with a history of pancreatitis Those currently taking other diabetes treatment medications orally or by injection
Risk of side effects Please remove the tablet from the aluminum foil just before taking Liberasus. Due to its sensitivity to moisture and light, storing the tablets exposed may prevent the medication from working effectively. To ensure the medication works properly, avoid splitting or crushing the tablets before taking them. Doing so may not only reduce the effectiveness of the medication but could also increase the risk of side effects.

Inquiries & Reservations

Please feel free to contact us.

Reception Hours: 10:00~18:00 03-6228-5707
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