Taken once a day, about an hour before sexual activity, it stimulates penile erection and lubricates sexual activity.
It is also sometimes called the Weekend Pill because if taken on Friday night, the effect lasts until noon on Sunday (up to 36 hours or so).
Used by more than 10 million people in more than 100 countries, Cialis is the No. 1 ED treatment in the world in 2013.
The long-lasting effects and the fact that it is not affected by food are factors that take the rush and pressure off patients, making it a favorite of many.
We are able to purchase our products in single pill units. You can purchase as much as you need, when you need it.
You can also purchase in bulk after you have tried it.
The mechanism of action is based on inhibiting the action of PDE-5. When men become sexually aroused, nitric oxide is released into the penis, increasing the concentration of cGMP (cyclic guanosine phosphate) in the penile sponge. cGMP relaxes penile smooth muscle and causes blood to flow into the sponge, resulting in an erection. PDE-5 destroys cGMP, so inhibiting the action of PDE-5 PDE-5 inhibits the action of cGMP and restores a normal erection.
Tadalafil, the active ingredient in Cialis, supports erection only when a man is sexually aroused.
Because of its very fast absorption into the body, the average maximum plasma concentration (Cmax) of tadalafil is reached in an average of two hours after taking the drug.
The drug is rapidly broken down by the body. In the absence of serious illness, the average clearance of tadalafil is 2.5 l / h.
The drug has a long half-life of 17.5 hours and should ideally be taken once a day.
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