Xenical is a medication that inhibits fat absorption in the body to treat obesity.
The active ingredient in Xenical, “Orlistat,” weakens the action of the digestive enzyme “lipase” found in the liver.
Lipase is an enzyme responsible for breaking down fat.
Orlistat inhibits lipase activity, thereby suppressing the absorption of fat from ingested food.
By inhibiting lipase activity, fat is less likely to be absorbed from the small intestine, preventing fat accumulation in the body.
Reference: Orlistat (marketed as Alli and Xenical) Information/ U.S. FOOD & DRUG
Unabsorbed fat is excreted as stool 1-2 days later. It is said that approximately 30% of dietary fat intake is excreted.
For those who enjoy fatty meals, taking Xenical can help prevent obesity caused by fat intake.
Reference: XENical in the Prevention of Diabetes in Obese Subjects (XENDOS) Study/Jarl S. Torgerson, MD, PHD
Reference: Recent usage status of orlistat overseas / Yoshio Ikeda
Reference: This module reflects the initial scientific discussion for the approval of Xenical. This scientific
discussion has been updated until 1 November 2003. For information on changes after this date
please refer to module 8B /SCIENTIFIC DISCUSSION
Reference: XENICAL, INN-orlistat / ema.europa.eu
Reference: FDA Drug Safety Communication: Completed safety review of Xenical/Alli (orlistat) and severe liver injury / U.S. FOOD & DRUG
Suppresses absorption of 30% of dietary fat.
The main ingredient orlistat acts on the liver,
Absorption is inhibited.
This allows you to feel the effects of your diet.
Xenical can be taken 1 tablet at a time, up to 3 times a day.
Depending on your current weight and the body type you want to achieve, your doctor may instruct you to take the medication less frequently.
If your doctor tells you how many times to take the medicine, follow his or her instructions.
The dosage of Xenical can be adjusted up to three times a day depending on the individual’s needs.
Side effects | Oil spots, gas during defecation, stool containing oil, excretion of oil, increased frequency of defecation, lack of fat-soluble vitamins, etc. |
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Precautions |
When using Xenical, we recommend that you try to go to the toilet frequently. Because this medicine eliminates the fat from the food you eat, your stools will be more oily than usual. Your stools may become loose and may pass without you even noticing. Your stools may be oilier than usual, which may make cleaning the toilet more difficult. |
Precautions |
When using Xenical, your skin may feel dry. For people who have a diet that does not consume much oil on a daily basis, Xenical may cause oil to be excreted from the body, resulting in a lack of oil in the body. As a result, your skin may lack moisture and feel dry. When we think of skin moisture, we tend to think of water, but in fact, oil also plays an important role. A lack of oil can cause the skin to lose its balance between moisture and oil, which can worsen skin conditions. |
Precautions |
As oil is excreted from the body, vitamins that dissolve in oil, called fat-soluble vitamins, are also easily excreted along with them. Excretion of vitamins may worsen the skin condition. To prevent vitamin deficiency, use Xenical while supplementing with vitamins such as supplements. |
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